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antibody af1168  (R&D Systems)


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    R&D Systems antibody af1168
    Antibody Af1168, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/antibody+af1168/Human+APP%2FProtease+Nexin+II+Pan+Specific+Antibody/pmc12491701-111-6-8
    Average 93 stars, based on 7 article reviews
    antibody af1168 - by Bioz Stars, 2026-10
    93/100 stars

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    other:

    Article Title: Discovery of an APP-Selective BACE1 Inhibitor for Alzheimer’s Disease
    Article Snippet: sAPPα was assessed by AlphaLISA comprising antibody AF1168 (R&D Systems catalog # AF1168) conjugated with Perkin Elmer acceptor beads (catalog # 6772001) and 2B3 antibody from IBL catalog # 11088 biotinylated and streptavidin donor beads.

    Article Title: Discovery of an APP-selective BACE1 inhibitor for Alzheimer's disease
    Article Snippet: sAPPα was assessed by AlphaLISA comprising antibody AF1168 (R&D Systems catalog # AF1168) conjugated with Perkin Elmer acceptor beads (catalog # 6772001) and 2B3 antibody from IBL catalog # 11088 biotinylated and streptavidin donor beads.

    Incubation:

    Article Title: Discovery of an APP-selective BACE1 inhibitor for Alzheimer's disease.
    Article Snippet: .. Afterwards, 2 μL of donor beads was added to each well, followed by a 30-min incubation in the dark, after which the signal was read. sAPPα sAPPαwas assessed by AlphaLISA comprising antibody AF1168 (R&D Systems catalog # AF1168) conjugated with Perkin Elmer acceptor beads (catalog # 6772001) and 2B3 antibody from IBL catalog # 11088 biotinylated and streptavidin donor beads. ..



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    Inhibitory activity and brain permeability of FAH65E(-) . Shown are (A) dose-response curves for FAH65 racemate and the FAH65E(+) and (-) enantiomers in the P5-P5′ assay and (B) sAPPβ and (C) Aβ1-42 in CHO-7W cells after treatment with increasing concentrations of FAH65 racemate and enantiomers. Legend in B also applies to C. Data graphed as the mean and SEM. (D) FAH65E(-) (black line) and sAPP β (blue dashed line) levels in brain from ApoE4TR-5XFAD mice after oral delivery of 30 ​mg/kg FAH65E(-) doses are shown. PK-PD study design did not include 0 h timepoint untreated mice but included time points 1, 2, 4 and 6 ​h after last dose on Day 2. N ​= ​3 mice per time point.

    Journal: Neurotherapeutics

    Article Title: Discovery of an APP-selective BACE1 inhibitor for Alzheimer's disease

    doi: 10.1016/j.neurot.2025.e00610

    Figure Lengend Snippet: Inhibitory activity and brain permeability of FAH65E(-) . Shown are (A) dose-response curves for FAH65 racemate and the FAH65E(+) and (-) enantiomers in the P5-P5′ assay and (B) sAPPβ and (C) Aβ1-42 in CHO-7W cells after treatment with increasing concentrations of FAH65 racemate and enantiomers. Legend in B also applies to C. Data graphed as the mean and SEM. (D) FAH65E(-) (black line) and sAPP β (blue dashed line) levels in brain from ApoE4TR-5XFAD mice after oral delivery of 30 ​mg/kg FAH65E(-) doses are shown. PK-PD study design did not include 0 h timepoint untreated mice but included time points 1, 2, 4 and 6 ​h after last dose on Day 2. N ​= ​3 mice per time point.

    Article Snippet: Media was assayed using an AlphaLISA for Aβ1-42 (Perkin Elmer catalog # AL276C), sAPPα (R&D Systems catalog # AF1168 conjugated with Perkin Elmer acceptor beads catalog # 6772001 + 2B3 antibody from IBL catalog # 11088 biotinylated), and sAPPβ (Perkin Elmer AL276-acceptor + IBL catalog # 18957 biotinylated).

    Techniques: Activity Assay, Permeability